Table 3:

Geometric mean antibody titers to Ebola glycoprotein

Dose/study day	No. of participants	GMT (95% CI)	p value for GMT/day 28				Seroconversion
Dose/study day	No. of participants	GMT (95% CI)	Placebo	1 × 10⁵ pfu	5 × 10⁵ pfu	3 × 10⁶ pfu	n (%)	p value
1 × 10 (5) pfu
0	10	27.7 (–)					NA	NA
7	10	27.7 (–)					0	1.0
14	10	96.8 (36.9–253.7)	0.015	NA	0.790	0.188	4 (40)	0.087
28	10	636.2 (258.6–1565.2)	< 0.001	NA	0.894	0.071	7 (70)	0.003
56	10	824.9 (341.7–1991.4)					8 (80)	< 0.001
84	10	993.6 (469.6–2102.1)					9 (90)	< 0.001
180	9	1169.7 (586.4–2333.2)	< 0.001	NA	0.537	0.488	8 (88.9)	< 0.001
5 × 10 (5) pfu
0	10	27.7 (–)					NA	NA
7	10	27.7 (–)					0	1.0
14	10	110.5 (34.0–359.1)	0.008	0.790	NA	0.290	2 (20)	0.474
28	10	603.5 (286.0–1273.5)	< 0.001	0.894	NA	0.054	7 (70)	0.003
56	10	792.8 (279.1–2252.2)					8 (80)	< 0.001
84	10	876.7 (410.1–1874.3)					8 (80)	< 0.001
180	10	928.1 (481.4–1789.4)	< 0.001	0.537	NA	0.924	10 (100)	< 0.001
3 × 10 (6) pfu
0	10	27.7 (–)					NA	NA
7	10	27.7 (–)					0	1.0
14	10	187.3 (126.0–278.4)	< 0.001	0.188	0.290	NA	4 (40)	0.087
28	10	1321.3 (830.2–2102.9)	< 0.001	0.071	0.054	NA	10 (100)	< 0.001
56	10	1152.6 (771.3–1722.5)					10 (100)	< 0.001
84	9	992.6 (583.3–1689.1)					9 (100)	< 0.001
180	9	895.7 (437.2–1835.1)	< 0.001	0.488	0.924	NA	8 (88.9)	< 0.001
Placebo
0	10	27.7 (–)					NA	NA
7	10	27.7 (–)					NA	NA
14	10	27.7 (–)	NA	0.015	0.008	< 0.001	NA	NA
28	10	27.7 (–)	NA	< 0.001	< 0.001	< 0.001	NA	NA
56	9	27.7 (–)					NA	NA
84	10	27.7 (–)					NA	NA
180	10	30.9 (24.0–39.8)	NA	< 0.001	< 0.001	< 0.001	NA	NA

Note: CI = confidence interval, GMT = geometric mean titers, NA = not applicable, pfu = plaque-forming units.