Analyses of variables associated with all-cause death and death attributable to Clostridium difficile infection
| Variable | All-cause death | Death attributable to C. difficile infection | ||
|---|---|---|---|---|
| OR (95% CI)* | Adjusted OR (95% CI)† | OR (95% CI)* | Adjusted OR (95% CI)† | |
| Sex | ||||
| Female | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) |
| Male | 1.07 (0.85–1.35) | 1.15 (0.91–1.46) | 1.25 (0.85–1.82) | 1.34 (0.91–1.97) |
| Age group, yr | ||||
| 18–64 | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) |
| ≥ 65 | 2.86 (2.09–3.90) | 2.73 (1.99–3.74) | 2.78 (1.65–4.68) | 2.45 (1.44–4.16) |
| NAP strain type | ||||
| Non-NAP1 | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) |
| NAP1 | 1.54 (1.22–1.95) | 1.26 (0.99–1.60) | 2.36 (1.51–3.47) | 1.91 (1.29–2.82) |
| Leukocyte count, ×109/L | ||||
| ≤ 15 | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) | 1.00 (ref.) |
| > 15 | 2.53 (2.00–3.21) | 2.43 (1.91–3.10) | 3.25(2.22–4.76) | 2.96 (2.01–4.35) |
| Albumin level, g/L | ||||
| > 30 | 1.00 (ref.) | – | 1.00 (ref.) | – |
| ≤ 30 | 2.03 (1.31–3.14) | – | 4.46 (1.77–11.26) | – |
Note: CI = confidence interval, OR = odds ratios, ref. = reference.
↵* Unadjusted OR: Bivariable tests of association between each variable and outcome.
↵† Adjusted OR: Multivariable tests of association between each variable and the outcome, adjusting for all other variables. Albumin was excluded from the multivariable logistic regression because of low number of cases (only 1180 patients [43.9%] had the data available).