Non-study drug procedures and treatments used in the perioperative period
| Procedure or treatment | Study group; no. (%) of patients*† | |
|---|---|---|
| Curcumin n = 304 | Placebo n = 302 | |
| IV fluids and antibiotics | ||
| Before repair | ||
| Volume of fluids given | ||
| None | 102 (34) | 100 (33) |
| < 100 mL | 16 (5) | 18 (6) |
| 100 to 500 mL | 139 (46) | 138 (46) |
| > 500 mL | 47 (15) | 46 (15) |
| Sodium bicarbonate | 12 (4) | 9 (3) |
| Prophylactic antibiotics | 254 (84) | 258 (85) |
| Vancomycin | 16 (6) | 18 (6) |
| Aminoglycoside | 13 (4) | 14 (5) |
| During repair | ||
| Volume of fluids given, L, median (IQR) | 2.7 (2.0 to 4.0) | 2.5 (1.9 to 4.0) |
| Colloids | 64 (21) | 57 (19) |
| Mannitol | 19 (6) | 16 (5) |
| Furosemide | 5 (2) | 5 (2) |
| Inotrope or vasopressor | 175 (58) | 190 (63) |
| Medications received in 24 h before repair | ||
| ACE-I or ARB | 84 (28) | 91 (30) |
| Oral diuretic | 39 (13) | 40 (13) |
| Antiplatelet drug, including ASA | 127 (42) | 120 (40) |
| Type of anesthesia | ||
| General | 265 (87) | 275 (91) |
| Neuraxial | 166 (55) | 140 (46) |
| Surgical procedure performed | ||
| Endovascular | 153 (50) | 167 (55) |
| Open, or endovascular and open | 151 (50) | 135 (45) |
| Use of suprarenal clamp | 27 (9) | 19 (6) |
| Use of IV contrast | 153 (50) | 166 (55) |
| Renal artery revascularization | 29 (10) | 22 (7) |
| Lower limb revascularization | 35 (12) | 31 (10) |
| Medications received in 24 h after repair | ||
| ACE-I or ARB | 90 (30) | 84 (28) |
| Oral diuretic | 58 (19) | 53 (18) |
| Antiplatelet drug, including ASA | 205 (67) | 214 (71) |