Table 5:

Association between maternal prepregnancy surgery and neonatal abstinence syndrome in newborns of women with no pain comorbidity

Maternal characteristicsNo. of infantsNo. of infants with neonatal abstinence syndromePrevalence per 10 000 (95% CI)Risk ratio (95% CI)*
Surgery
 Yes607 38690214.9 (13.9–15.8)1.74 (1.59–1.91)
 No1 426 21011798.3 (7.8–8.7)Referent
Total no. of hospital admissions for surgery
 01 426 21011798.3 (7.8–8.7)Referent
 1400 77748712.2 (11.1–13.2)1.46 (1.30–1.63)
 2132 17321916.6 (14.4–18.8)1.94 (1.67–2.26)
 ≥ 374 43619626.3 (22.6–30.0)3.04 (2.59–3.57)
Total no. of surgeries
 01 426 21011798.3 (7.8–8.7)Referent
 1304 77434311.3 (10.1–12.4)1.36 (1.20–1.54)
 2141 12920414.5 (12.5–16.4)1.66 (1.42–1.94)
 ≥ 3161 48335522.0(19.7–24.3)2.89 (2.28–2.93)
Type of anesthesia used for surgery
 General515 85478315.2 (14.1–16.2)1.79 (1.62–1.96)
 Local or regional only91 53211913.0 (10.7–15.3)1.52 (1.24–1.85)
 No surgery1 426 21011798.3 (7.8–8.7)Referent
Age at first surgery, yr
 < 15119 26726222.0 (19.3–24.6)2.50 (2.14–2.91)
 15–19128 39524118.8 (16.4–21.1)1.99 (1.68–2.27)
 20–24146 88421214.4 (12.5–16.4)1.69 (1.45–1.97)
 ≥ 25212 8401878.8 (7.5–10.0)1.19 (1.01–1.40)
 No surgery1 426 21011798.3 (7.8–8.7)Referent
Time between first surgery and future pregnancy, yr
 < 5250 38826810.7 (9.4–12.0)1.25 (1.09–1.44)
 5–9151 27123415.5 (13.5–17.4)1.81 (1.56–2.09)
 ≥ 10205 72740019.4 (17.5–21.3)2.53 (2.23–2.87)
 No surgery1 426 21011798.3 (7.8–8.7)Referent

  • Note: CI = confidence interval.

  • ↵* Adjusted for maternal mental illness, age at delivery, parity, socioeconomic deprivation, place of residence and time period at birth.