Adjusted model estimates of risk factors for intensive care unit admission for patients admitted to hospital with multisystem inflammatory syndrome in children*
Variable | Absolute risk, % (95% CI) | Risk difference, % (95% CI) | Relative risk (95% CI) |
---|---|---|---|
Age, yr | |||
0–5 | 18.4 (11.6 to 25.2) | – | – |
6–12 | 43.6 (34.4 to 52.8) | 25.2 (13.6 to 36.9) | 2.37 (1.34 to 3.40) |
13–18 | 46.2 (28.2 to 64.1) | 27.7 (8.3 to 47.2) | 2.51 (1.14 to 3.88) |
Sex | |||
Male | 28.0 (21.3 to 34.8) | – | – |
Female | 35.6 (27.7 to 43.5) | 7.6 (−2.9 to 18.1) | 1.27 (0.85 to 1.69) |
Country | |||
Canada | 34.7 (28.5 to 40.9) | – | – |
Costa Rica | 9.2 (1.0 to 17.4) | −25.5(−36.0 to −15.0) | 0.26 (0.03 to 0.51) |
Iran | 58.7 (28.5 to 40.9) | 24.0 (2.3 to 50.9) | 1.69 (0.95 to 2.43) |
Initial leukocyte count, × 109/L† | |||
< 5 | 29.2 (14.6 to 43.9) | −1.1 (−17.2 to 15.0) | 0.96 (0.44 to 1.49) |
5–15 | 30.3 (24.1 to 36.6) | – | – |
> 15 | 33.2 (20.2 to 46.2) | 2.9 (−11.8 to 17.5) | 1.10 (0.60 to 1.59) |
Initial platelet count, × 109/L† | |||
< 150 | 33.8 (23.6 to 44.0) | 2.9 (−9.4 to 15.2) | 1.09 (0.69 to 1.50) |
≥ 150 | 30.9 (24.8 to 37.1) | – | – |
Initial ferritin, μg/L† | |||
≤ 500 | 26.6 (20.9 to 32.5) | – | – |
> 500 | 45.1 (33.8 to 56.4) | 18.4 (5.6 to 31.3) | 1.69 (1.12 to 2.26) |
Gastrointestinal involvement | 30.4 (25.2 to 35.6) | −11.7 (−30.3 to 6.9) | 0.72 (0.39 to 1.05) |
Mucocutaneous involvement | 32.6 (27.0 to 38.1) | 7.4 (−6.8 to 21.5) | 1.29 (0.59 to 1.99) |
Admission period | |||
Mar. 1–Nov. 1, 2020 | 24.9 (16.8 to 33.0) | – | – |
Nov. 1, 2020–Mar. 7, 2021 | 37.2 (28.9 to 45.6) | 12.3 (−0.3 to 25.0) | 1.50 (0.86 to 2.13) |
Note: CI = confidence interval.
↵* Models are adjusted for sex, age, country, presence of comorbidity, coinfection, confirmed case status, treatment and admission time. Average marginal effects are presented with adjusted risk differences from multivariable logistic regressions.
↵† Number of observations differing from complete data set of 232, leukocytes: 4 missing; platelets: 2 missing; ferritin: 7 missing.