User profiles for David S. Guttman

David S. Guttman

Professor, University of Toronto
Verified email at utoronto.ca
Cited by 22096

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months

MB Azad, T Konya, H Maughan, DS Guttman, CJ Field… - Cmaj, 2013 - Can Med Assoc
Background: The gut microbiota is essential to human health throughout life, yet the acquisition
and development of this microbial community during infancy remains poorly understood. …

Assembly and ecological function of the root microbiome across angiosperm plant species

…, J Copeland, PW Wang, DS Guttman… - Proceedings of the …, 2018 - National Acad Sciences
Across plants and animals, host-associated microbial communities play fundamental roles
in host nutrition, development, and immunity. The factors that shape host–microbiome …

Disentangling interactions in the microbiome: a network perspective

M Layeghifard, DM Hwang, DS Guttman - Trends in microbiology, 2017 - cell.com
Microbiota are now widely recognized as being central players in the health of all organisms
and ecosystems, and subsequently have been the subject of intense study. However, …

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study

…, T Konya, RR Persaud, DS Guttman… - … Journal of Obstetrics …, 2016 - Wiley Online Library
Objective Dysbiosis of the infant gut microbiota may have long‐term health consequences.
This study aimed to determine the impact of maternal intrapartum antibiotic prophylaxis ( IAP ) …

Evolution of the Core Genome of Pseudomonas syringae, a Highly Clonal, Endemic Plant Pathogen

SF Sarkar, DS Guttman - Applied and environmental microbiology, 2004 - Am Soc Microbiol
Pseudomonas syringae is a common foliar bacterium responsible for many important plant
diseases. We studied the population structure and dynamics of the core genome of P. …

Association of host genome with intestinal microbial composition in a large healthy cohort

…, MS Silverberg, D Kevans, MI Smith, DS Guttman… - Nature …, 2016 - nature.com
Intestinal microbiota is known to be important in health and disease. Its composition is
influenced by both environmental and host factors. Few large-scale studies have evaluated the …

[PDF][PDF] Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells

…, SE Girardin, TMS Wolever, W Edelmann, DS Guttman… - Cell, 2014 - cell.com
The etiology of colorectal cancer (CRC) has been linked to deficiencies in mismatch repair
and adenomatous polyposis coli (APC) proteins, diet, inflammatory processes, and gut …

Infant gut microbiota and food sensitization: associations in the first year of life

MB Azad, T Konya, DS Guttman… - Clinical & …, 2015 - Wiley Online Library
Background The gut microbiota is established during infancy and plays a fundamental role
in shaping host immunity. Colonization patterns may influence the development of atopic …

A Functional Screen for the Type III (Hrp) Secretome of the Plant Pathogen Pseudomonas syringae

DS Guttman, BA Vinatzer, SF Sarkar, MV Ranall… - Science, 2002 - science.org
Type III secreted “effector” proteins of bacterial pathogens play central roles in virulence, yet
are notoriously difficult to identify. We used an in vivo genetic screen to identify 13 effectors …

[HTML][HTML] Lung microbiota across age and disease stage in cystic fibrosis

…, YCW Yau, VJ Waters, DM Hwang, DS Guttman - Scientific reports, 2015 - nature.com
Understanding the significance of bacterial species that colonize and persist in cystic fibrosis
(CF) airways requires a detailed examination of bacterial community structure across a …