• Oral medications traditionally used for the prevention of migraine and known to be effective
include anti-epileptic, β-blocker, antihypertensive and antidepressant drugs.• …

The evidence base for migraine prevention in both episodic and chronic migraine is
outlined. The older oral preventatives, including antidepressants, antihypertensives …

Frequent, severe and long-lasting migraine attacks require prophylaxis. Established drugs
used for the prevention of migraine such as β-adrenoceptor antagonists (β-blockers) …

Prophylactic migraine therapy: Mechanisms and evidence Page 1 Prophylactic Migraine
Therapy: Mechanisms and Evidence Nabih M. Ramadan, MD Address Clinical & External Affairs …

Migraine therapeutics are pharmacological, including acute and preventive,
nonpharmacological and/or both. Preventive pharmacological strategies serendipitously …

A variety of drugs from diverse pharmacological classes are in use for migraine prevention.
Traditionally, they have been discovered by serendipity. Examples include β‐adrenergic …

There are only a handful of drugs that have been submitted for and received an indication
for the preventative treatment of migraine by the US Food and Drug Administration, as well …

Migraine is a paroxysmal disorder with attacks of headache, nausea, vomiting, photo-and
phonophobia and malaise. This review summarises new treatment options both for the …

Migraine is a common neurological disorder that afflicts≥ 12% of the adult US population.
Severe, frequent and disabling attacks require effective prophylaxis. Traditional preventive …

Several cellular and molecular mechanisms have been implicated in migraine
pathophysiology including abnormal neuronal excitability and vascular events. Drugs from …