Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the Polycomb …

We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …

The transcriptional regulatory networks that specify and maintain human tissue diversity are
largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation …

The transcription factors OCT4, SOX2, and NANOG have essential roles in early development
and are required for the propagation of undifferentiated embryonic stem (ES) cells in …

Background Trials of statin therapy have had conflicting findings on the risk of development
of diabetes mellitus in patients given statins. We aimed to establish by a meta-analysis of …

In order to develop some understanding of the evolution of cortical contusions, interdisciplinary
studies including behavior, morphology and histochemistry were conducted at varying …

Triantennary N-acetyl galactosamine (GalNAc, GN3), a high-affinity ligand for the hepatocyte-specific
asialoglycoprotein receptor (ASGPR), enhances the potency of second-generation …

The presence of an ulcer beneath callus on the diabetic foot has been a well‐documented
and common clinical finding. We have conducted a prospective study to examine whether …

ECTOPIC PREGNANCY IS A LIFE- AND FERTILITY-threatening condition that is commonly
seen in Canadian emergency departments. Increases in the availability and use of hormonal …

Background The West of Scotland Coronary Prevention Study was a randomized clinical trial
comparing pravastatin with placebo in men with hypercholesterolemia who did not have a …