An emerging series of papers has identified new receptor proteins that predict seven-transmembrane
pass topologies. We have consolidated this family to 11 human genes and have …

The R-Spondin (RSpo) family of secreted proteins act as potent activators of the Wnt/β-catenin
signaling pathway. We have previously shown that RSpo proteins can induce proliferative …

Abstract Development of therapeutics for genetically complex neurodegenerative diseases
such as sporadic amyotrophic lateral sclerosis (ALS) has largely been hampered by lack of …

The interaction of amyloid-beta (Aβ) and tau in the pathogenesis of Alzheimer's disease is a
subject of intense inquiry, with the bulk of evidence indicating that changes in tau are …

Introduction: Pathologic accumulation and activation of mast cells and eosinophils are
implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (…

The C-terminal domains of the A, B, C chains of C1q subcomponent of C1 complex represent
a common structural motif, the C1q domain, that is found in a diverse range of proteins. We …

Objective During the course of different musculoskeletal diseases, joints are progressively
damaged by inflammatory, infectious, or mechanical stressors, leading to joint destruction and …

Background: In Canada, low awareness of evidence-based interventions for the clinical
management of alcohol use disorder exists among health care providers and people who could …

Pathogenic variants in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified
that increase the risk for developing Parkinson’s disease in a dominantly inherited fashion. …

Drosophila Crossveinless-2 (dCV-2) is required for local activation of Mad phosphorylation
in the fruit fly wing and has been postulated to be a positive regulator of BMP-mediated …