The hypothalamic-pituitary-adrenal (HPA) axis is a major component of the systems that
respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly …

Appropriate interactions between serotonin (5-HT) and stress pathways are critical for
maintaining homeostasis. Dysregulation of hypothalamic-pituitary-adrenal (HPA) stress axis is a …

Male and females appear equally capable of showing habituated hypothalamic-pituitary-adrenal
(HPA) axis output responses to repeated exposures of the same challenge. Whether …

Sex‐biased neuropsychiatric disorders, including major depressive disorder and schizophrenia,
are the major cause of disability in the developed world. Elevated stress sensitivity has …

The prevalence of affective disorders is two times greater in women than in men. The onset
of anxiety and depression occurs at different ages that may correspond to key developmental …

… Nirupa Goel and Leyla Innala conducted the studies. Nirupa Goel was responsible for the
collection of data and statistical analysis. Nirupa Goel and Victor Viau wrote the manuscript, …

Background: In Canada, low awareness of evidence-based interventions for the clinical
management of alcohol use disorder exists among health care providers and people who could …

The higher incidence of stress-mediated affective disorders in women may be a function of
gonadal hormone influence on complex interactions between serotonin and neural circuits …

Stress-induced affective disorders, such as depression and anxiety, are more prevalent in
females than in males. The reduced vulnerability to these disorders in males may be due to …

Puberty is a plastic period of neurological development when critical maturation of stress
pathways occurs. Abnormal maturation may be predictive of future stress sensitivity and …