Background: In Canada, low awareness of evidence-based interventions for the clinical
management of alcohol use disorder exists among health care providers and people who could …

Objective: Extensive exposure to prescription-type opioids has resulted in major harm worldwide,
calling for better-adapted approaches to opioid agonist therapy. The authors aimed to …

Amorphization is a commonly used method to enhance the dissolution of poorly water-soluble
drug. There are a number of different methods to generate amorphous drug substances …

Background Rates of non-medical use of opioids, and opioid use disorders (OUD) have
been rising throughout North America. Methadone and buprenorphine/naloxone are the …

Background Craving reduction is an important target in the treatment of prescription-type opioid
use disorder (POUD). In this exploratory analysis, we compared the effectiveness of BUP/…

Background Engagement and retention in opioid agonist therapy (OAT) remains a challenge.
This study evaluated the impact of initial randomized OAT allocation on subsequent …

Background and aims Fentanyl is primarily responsible for the current phase of the overdose
epidemic in North America. Despite the benefits of treatment with medications for opioid …

Background and Objectives Buprenorphine/naloxone (BUP‐NX) and methadone are used to
treat opioid use disorder (OUD), yet there is insufficient evidence on the impact of doses on …

Background Chronic pain has a major impact on a patient’s quality of life, affecting physical
and psychological functioning. It has debilitating consequences on social and economic …

IN THE past, few authors have proposed the abandonment of historical costing procedures,
but today many are pro-posing alternative valuation procedures. These alternative valuation …