Original Articles
Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis
Sachin Sud, Jan O. Friedrich, Neill K. J. Adhikari, Paolo Taccone, Jordi Mancebo, Federico Polli, Roberto Latini, Antonio Pesenti, Martha A.Q. Curley, Rafael Fernandez, Ming-Cheng Chan, Pascal Beuret, Gregor Voggenreiter, Maneesh Sud, Gianni Tognoni, Luciano Gattinoni and Claude Guérin
CMAJ May 26, 2014 cmaj.140081; DOI: https://doi.org/10.1503/cmaj.140081
Sachin Sud
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Jan O. Friedrich
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Neill K. J. Adhikari
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Paolo Taccone
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Jordi Mancebo
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Federico Polli
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Roberto Latini
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Antonio Pesenti
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Martha A.Q. Curley
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Rafael Fernandez
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Ming-Cheng Chan
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Pascal Beuret
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Gregor Voggenreiter
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Maneesh Sud
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Gianni Tognoni
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Luciano Gattinoni
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Claude Guérin
Institute for Better Health and Division of Critical Care (S. Sud), Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont.; Interdepartmental Division of Critical Care (S. Sud, Friedrich, Adhikari), University of Toronto, Toronto, Ont.; Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute (Friedrich), St. Michael's Hospital, Toronto, Ont.; Dipartimento di Anestesia e Rianimazione (Taccone, Gattinoni, Polli), Fondazione IRCCS — Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy; Istituto di Anestesiologia e Rianimazione (Polli, Gattinoni), Universita degli Studi di Milano, Milan, Italy; Dipartimento di Fisiopatologia Medico—Chirurgica e dei Trapianti (Gattinoni), Fondazione IRCCS Ca' Granda — Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy; Department of Critical Care Medicine (Adhikari), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont.; Department of Cardiovascular Research (Latini), Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Dipartimento di Medicina Perioperatoria e Terapie Intensive (Pesenti), Azienda Ospedaliera San Gerardo, Monza, Italy; Dipartimento di Medicina Sperimentale (Pesenti), Universita degli Studi di Milano—Bicocca, Milan, Italy; Service de Réanimation Médicale et Assistance Respiratoire (Guérin), Hôpital de la Croix-Rousse, Lyon, France; Servei de Medicina Intensiva (Mancebo), Hospital de Sant Pau, Barcelona, Spain; University of Pennsylvania School of Nursing (Curley), Philadelphia, Penn.; Intensive Care Unit (Fernandez), Hospital Sant Joan de Deu — Fundacio Althaia, CIBERES, Manresa, Spain; Universitat Internacional de Catalunya (Fernandez), Barcelona, Spain; Section of Chest Medicine (Chan), Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Physiology (Chan), National Yang-Ming University, Taipei, Taiwan; Service de Réanimation (Beuret), Centre Hospitalier, Roanne, France; Department of Orthopaedic and Trauma Surgery (Voggenreiter), Hospitals in the Natureparc Altmuhltal, Eichstatt, Germany; Faculty of Medicine (M. Sud), University of Toronto, Toronto, Ont.; Consorzio Mario Negri Sud (Tognoni), Santa Maria Imbaro, Italy.
Online Appendices
- Appendix 1: Amendments to previously described protocol for the systematic review of randomized controlled trials (RCTs) comparing the effect of prone positioning during mechanical ventilation on mortality among patients with
- Appendix 2: Details of literature search
- Appendix 3: Characteristics of the randomized controlled trials included in the systematic review (part 1 of 4)
- Appendix 4: Summary of findings: Prone ventilation versus supine ventilation for acute respiratory distress syndrome (ARDS)
- Appendix 5: GRADE Evidence profile for prone ventilation versus supine ventilation for acute respiratory distress syndrome (ARDS)