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Fig. 1: Biochemical pathways of homocysteine metabolism. Ser = serine; Gly = glycine; MTHF = methylenetetrahydrofolate; MTHFR = N5,N10-methylenetetrahydrofolate reductase; THF = tetrahydrofolate; SAM = S-adenosylmethionine; SAH = S-adenosylhomocysteine; DMG = dimethylglycine; CβS = cystathionineβ-synthase.