Fig. 3: When a diet is high in the omega-3 fatty acids EPA and DHA, they replace a portion of the AA in membrane phospholipids. This reduces the amount of AA available for liberation. In addition, liberated EPA and DHA inhibit the activity of COX. This results in reduced production of the proaggregatory compound thromboxane A2 (TxA2), leading to reduced platelet aggregation, making thrombus formation less likely. Photo by: Lianne Friesen and Nicholas Woolridge