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Figure 1: Figure 1: Model of obesity-induced adipose tissue dysfunction. Positive caloric balance leads to deposition of excess energy as triglyceride in subcutaneous adipose tissue. Defective adipogenesis may limit storage capacity, resulting in hypertrophied, inflamed and insulin-resistant adipocytes. Elevated levels of pro-inflammatory adipokines and free fatty acids are released inappropriately to visceral adipose tissue and to liver, muscle and pancreatic beta cells, which contributes to metabolic malfunction. Image by: Lianne Friesen and Nicholas Woolridge