Figure 1: Circle graph depicting the marked genotypic and phenotypic heterogeneity in hereditary colorectal cancer syndromes. Circles indicate as yet undiscovered variants of heriditary cancers. Note: AC-1 = Amsterdam Criteria I, MMR = mismatch repair, FAP = familial adenomatous polyposis, AFAP = attenuated familial adenomatous polyposis, HBCC = hereditary breast and colorectal cancer, PJS = Peutz–Jeghers syndrome, FJP = familial juvenile polyposis, CD = Cowden disease, BRRS = Bannayan–Ruvalcaba–Riley syndrome. Modified with permission from The American Cancer Society, Inc. 1