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- Page navigation anchor for RE: Inorganic phosphate toxicity a cause for concern and careRE: Inorganic phosphate toxicity a cause for concern and care
Inorganic phosphate is present mostly in bone and teeth ( around 80 percent). The remaining Pi is present in viscera, skeletal muscle and with a very little present in the Extracellular fluid. It is important for nearly 2000 reactions in the body. Vitamin D, Parathormone and Fibroblast growth factor (FGF 23) are key regulators of phosphate homeostasis in the body. Any of these factors alone or in combination are dysfunctional or dysregulated Pi balance will be affected. Particularly FGF 23 suppression can cause hyperphosphatemia leading to its toxicity and tissue damage.
Common causes of phosphate toxicity in humans include impaired renal function, rhabdomyolysis, and tumor lysis syndrome. In addition, exogenous phosphate toxicity is also documented in patients with Hirschsprung disease when exposed to hypertonic phosphate enema. Phosphate toxicity can cause impaired fertility, Increased cell death, impaired cell signaling, premature aging, vascular calcification, renal dysfunction, and increased tumorigenesis. Therefore, a recollection of phosphate toxicity is essential in the present day health context as one of the major risk factors for tissue damage.Competing Interests: None declared.