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Drug-induced liver injury
Alexander Kumachev and Peter E. Wu
CMAJ March 01, 2021 193 (9) E310; DOI: https://doi.org/10.1503/cmaj.202026
Alexander Kumachev
Department of Medicine (Kumachev, Wu) and Divisions of Clinical Pharmacology and Toxicology (Kumachev, Wu) and General Internal Medicine (Wu), University of Toronto, Toronto, Ont.
MD MScPeter E. Wu
Department of Medicine (Kumachev, Wu) and Divisions of Clinical Pharmacology and Toxicology (Kumachev, Wu) and General Internal Medicine (Wu), University of Toronto, Toronto, Ont.
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Drug-induced liver injury
Alexander Kumachev, Peter E. Wu
CMAJ Mar 2021, 193 (9) E310; DOI: 10.1503/cmaj.202026
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- Drug-induced liver injury can be caused by a variety of medications, supplements and herbal products (Appendix 1, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.202026/tab-related-content)
- Drug-induced liver injury should be suspected in patients with new elevation of liver enzymes, prompting a review of drug exposures dating back as far as 3 months
- Diagnosis requires exclusion of alternate causes
- In most cases, resolution of drug-induced liver injury occurs after drug discontinuation
- Treatment requires identification and discontinuation of the culprit drug
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